Adaptive Optics Imaging as a Novel Clinical Trial Endpoint for Retinal Gene Therapy

The “Adaptive Optics Imaging as a Novel Clinical Trial Endpoint for Retinal Gene Therapy” project will enhance the long-standing relationship that the Centre for Eye Research Australia (CERA) has with the University of Melbourne. 

Project Overview:
Industry Researcher PhD Candidate Bhaj Grewal, under the supervision of A/Prof Lauren Ayton, Dr. Phillip Bedggood, Alexis Ceecee Britten-Jones, Andrew Metha and Prof Keith Martin, will develop new outcome measures, accelerating drug discovery and improving patient care with the aim of revolutionizing clinical trials for inherited retinal diseases using adaptive optics, a cutting-edge imaging technique monitoring disease progression at a cellular level. Integration of adaptive optics not only streamlines clinical trials but also advances our understanding of disease progression, paving the way for targeted therapies. Expected outcomes include faster drug discovery, cost-effective treatments, and improved clinical care for patients with inherited retinal diseases.